Tropical splenomegaly syndrome in New Guinea II. Long term results of splenectomy
Identifieur interne : 003B06 ( Main/Exploration ); précédent : 003B05; suivant : 003B07Tropical splenomegaly syndrome in New Guinea II. Long term results of splenectomy
Auteurs : G. G. Crane [Guinée, Royaume-Uni] ; D. S. Pryor [Guinée, Royaume-Uni] ; J. Vivian Wells [Guinée, Royaume-Uni]Source :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1972.
English descriptors
- Teeft :
- Autopsy material, Blood transfusion, Blood volume estimations, Blood volume studies, Cell pool, Cell survival time, Cell volume, Control group, Early phase, Gross splenomegaly, Haematology research unit, Haemoglobin, Haemoglobin level, Haemoglobin values, Human biology, Immunoglobulin, Immunoglobulin fractions, Intravascular pools, Leucocyte, Leucocyte count, Leucocyte counts, Lymphocyte, Major site, Mortality rate, Other diseases, Plasma volume, Plasma volumes, Platelet, Platelet counts, Present address, Progressive hepatic enlargement, Pryor, Serum concentrations, Serum level pool, Spleen, Splenectomy, Splenic, Splenic pool, Splenomegaly, Syndrome, Terminal illnesses, Tropical splenomegaly syndrome, Vivian wells, Watut valley, Watut valley natives, Wellcome trust.
Abstract
Between 1965 and 1967 splenectomy was performed on 21 Watuts and 5 other New Guineans to relieve persistent incapacitating symptoms of tropical splenomegaly syndrome. There were 3 operative deaths. Post-operatively abolition of the splenic red cell pool, correction of the shortened red cell survival time and reduction in plasma volume occurred, leading to a mean rise in haemoglobin concentration of 3·7 g./100 ml. Neutropenia and thrombocytopenia were also corrected. There was a rapid post-operative fall in serum IgG and IgM concentrations, and a prolonged reduction in intravascular pools of both immunoglobulin fractions. The 18 Watuts discharged from hospital and followed for from 41 to 74 months have had significant symptomatic relief, although 7 have died following short illnesses; this mortality rate (36%) is substantially less than that of a comparable group of Watuts not subjected to splenectomy.
Url:
- https://api.istex.fr/ark:/67375/HXZ-3JD9KN93-1/fulltext.pdf
- https://api.istex.fr/ark:/67375/6H6-26F3G6B1-0/fulltext.pdf
DOI: 10.1016/0035-9203(72)90087-9
Affiliations:
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Le document en format XML
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<front><div type="abstract">Between 1965 and 1967 splenectomy was performed on 21 Watuts and 5 other New Guineans to relieve persistent incapacitating symptoms of tropical splenomegaly syndrome. There were 3 operative deaths. Post-operatively abolition of the splenic red cell pool, correction of the shortened red cell survival time and reduction in plasma volume occurred, leading to a mean rise in haemoglobin concentration of 3·7 g./100 ml. Neutropenia and thrombocytopenia were also corrected. There was a rapid post-operative fall in serum IgG and IgM concentrations, and a prolonged reduction in intravascular pools of both immunoglobulin fractions. The 18 Watuts discharged from hospital and followed for from 41 to 74 months have had significant symptomatic relief, although 7 have died following short illnesses; this mortality rate (36%) is substantially less than that of a comparable group of Watuts not subjected to splenectomy.</div>
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