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Tropical splenomegaly syndrome in New Guinea II. Long term results of splenectomy

Identifieur interne : 003B06 ( Main/Exploration ); précédent : 003B05; suivant : 003B07

Tropical splenomegaly syndrome in New Guinea II. Long term results of splenectomy

Auteurs : G. G. Crane [Guinée, Royaume-Uni] ; D. S. Pryor [Guinée, Royaume-Uni] ; J. Vivian Wells [Guinée, Royaume-Uni]

Source :

RBID : ISTEX:258778BA5DC262A467493A133209F51B88BFE587

English descriptors

Abstract

Between 1965 and 1967 splenectomy was performed on 21 Watuts and 5 other New Guineans to relieve persistent incapacitating symptoms of tropical splenomegaly syndrome. There were 3 operative deaths. Post-operatively abolition of the splenic red cell pool, correction of the shortened red cell survival time and reduction in plasma volume occurred, leading to a mean rise in haemoglobin concentration of 3·7 g./100 ml. Neutropenia and thrombocytopenia were also corrected. There was a rapid post-operative fall in serum IgG and IgM concentrations, and a prolonged reduction in intravascular pools of both immunoglobulin fractions. The 18 Watuts discharged from hospital and followed for from 41 to 74 months have had significant symptomatic relief, although 7 have died following short illnesses; this mortality rate (36%) is substantially less than that of a comparable group of Watuts not subjected to splenectomy.

Url:
DOI: 10.1016/0035-9203(72)90087-9


Affiliations:


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Le document en format XML

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<div type="abstract">Between 1965 and 1967 splenectomy was performed on 21 Watuts and 5 other New Guineans to relieve persistent incapacitating symptoms of tropical splenomegaly syndrome. There were 3 operative deaths. Post-operatively abolition of the splenic red cell pool, correction of the shortened red cell survival time and reduction in plasma volume occurred, leading to a mean rise in haemoglobin concentration of 3·7 g./100 ml. Neutropenia and thrombocytopenia were also corrected. There was a rapid post-operative fall in serum IgG and IgM concentrations, and a prolonged reduction in intravascular pools of both immunoglobulin fractions. The 18 Watuts discharged from hospital and followed for from 41 to 74 months have had significant symptomatic relief, although 7 have died following short illnesses; this mortality rate (36%) is substantially less than that of a comparable group of Watuts not subjected to splenectomy.</div>
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